Rei’s work colleague, Kurt, is a 53-year-old father, who has worked as a gardener all his life. He has been diagnosed with stage IVA melanoma. Kurt underwent removal of the melanoma on his left forearm and a nearby lymph node dissection 7 weeks ago. He has been receiving immunotherapy for his melanoma which has not been successful and therefore he has been placed on chemotherapy. Kurt has been experiencing weight loss over the last 2 months as well as a persistent cough and shortness of breath. A CT scan reveals several, well circumscribed, rounded structures in the periphery of his lungs. A lung biopsy is performed, which confirms the presence of melanoma cells in the structures observed on the CT image.
Question 2/9. Discuss the significance of Kurt’s CT and histology findings. (2 marks) 
Question 2/10 Further laboratory testing has indicated a p53 gene mutation in Kurt’s melanoma cells. Explain the possible link between Kurt’s p53 mutation and his melanoma, and considering Kurt’s profession, name a possible environmental factor that may have caused his mutation. (3 marks)